Journal of Pathology and Translational Medicine

Case Study

Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder: Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim; J Pathol Transl Med. 2018;52(2):121-125. Published online October 5, 2017; DOI: https://doi.org/10.4132/jptm.2017.08.20

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Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.

Citations

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Journal of Korean Medical Science.2023;[Epub] CrossRef
Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma
Man Jiang, Yijing Zhang
Journal of Cancer Research and Therapeutics.2023; 19(4): 910. CrossRef
Primary mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: A case report and literature review
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Asian Journal of Surgery.2022; 45(11): 2336. CrossRef
Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review
Xu Ren, Hong Jiang, Kan Sun, Xufu Qin, Yongping Qu, Tian Xia, Yan Chen
Diagnostic Pathology.2022;[Epub] CrossRef
Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature
Pengyan Wang, Jingci Chen, Ying Jiang, Congwei Jia, Junyi Pang, Shan Wang, Xiaoyan Chang, Oronzo Brunetti
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef
Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature
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Endocrine Pathology.2020; 31(1): 84. CrossRef
Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report
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World Journal of Surgical Oncology.2019;[Epub] CrossRef

Brief Case Report

Hyalinizing Cholecystitis and Associated Carcinoma: A Case Report: Youngjin Kang, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim; J Pathol Transl Med. 2018;52(1):64-66. Published online April 4, 2017; DOI: https://doi.org/10.4132/jptm.2016.11.04

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18F-FDG PET/CT in Hyalinized Cholecystitis
Esra Arslan, Aytül Hande Yardimci, Enver Yarikkaya, Göksel Alçin, Tevfik Fikret Çermik
Clinical Nuclear Medicine.2021; 46(4): e228. CrossRef
Gallbladder Carcinoma and Its Differential Diagnosis at MRI: What Radiologists Should Know
Camila Lopes Vendrami, Michael J. Magnetta, Pardeep K. Mittal, Courtney C. Moreno, Frank H. Miller
RadioGraphics.2021; 41(1): 78. CrossRef
A simple method for diagnosing gallbladder malignant tumors with subserosa invasion by endoscopic ultrasonography
Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohi
BMC Cancer.2021;[Epub] CrossRef
KRONİK KOLESİSTİTİN NADİR VE MALİGNİTE POTANSİYELİ YÜKSEK OLAN ALT TİPİ; HYALİNİZE KOLESİSTİT: OLGU SUNUMU
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Retraction

Notice of Retraction: Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats: Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Choe; J Pathol Transl Med. 2016;50(4):325-325. Published online July 15, 2016; DOI: https://doi.org/10.4132/jptm.2015.09.11.r; Retracts: J Pathol Transl Med 2015;49(6):472

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Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay
Eliana Baez-Jurado, Gina Guio Vega, Gjumrakch Aliev, Vadim V. Tarasov, Paula Esquinas, Valentina Echeverria, George E. Barreto
Molecular Neurobiology.2018; 55(3): 2285. CrossRef

Original Articles

Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats: Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Choe; J Pathol Transl Med. 2015;49(6):472-480. Published online October 16, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.11; Retraction in: J Pathol Transl Med 2016;50(4):325

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Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases: Hyunchul Kim, Ja-June Jang, Dong-Sik Kim, Beom Woo Yeom, Nam Hee Won; Korean J Pathol. 2013;47(5):411-417. Published online October 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.411

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Abstract PDF

Background

Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.

Methods

We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.

Results

Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.

Conclusions

Although the new classification is now generally accepted, validation through follow-up studies is necessary.

Citations

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Relevance of morphological features for hepatocellular adenoma classification in pathology practice
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The molecular functions of hepatocyte nuclear factors – In and beyond the liver
Hwee Hui Lau, Natasha Hui Jin Ng, Larry Sai Weng Loo, Joanita Binte Jasmen, Adrian Kee Keong Teo
Journal of Hepatology.2018; 68(5): 1033. CrossRef
Hepatocellular adenoma: Classification, variants and clinical relevance
Paulette Bioulac-Sage, Christine Sempoux, Charles Balabaud
Seminars in Diagnostic Pathology.2017; 34(2): 112. CrossRef
A Limited Immunohistochemical Panel Can Subtype Hepatocellular Adenomas for Routine Practice
Brent K. Larson, Maha Guindi
American Journal of Clinical Pathology.2017; 147(6): 557. CrossRef
Hepatocellular Neoplasms Arising in Association With Androgen Use
Sounak Gupta, Bita V. Naini, Richard Munoz, Rondell P. Graham, Benjamin R. Kipp, Michael S. Torbenson, Taofic Mounajjed
American Journal of Surgical Pathology.2016; 40(4): 454. CrossRef
Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
Taofic Mounajjed, Saba Yasir, Patrice A Aleff, Michael S Torbenson
Modern Pathology.2015; 28(9): 1265. CrossRef

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